Choose your gene
What are GRI Disorders?
GRI Disorders are rare single-gene disorders related to the GRIA, GRIK, GRID and GRIN genes. Many GRI patients are non-verbal, unable to walk, and many cannot feed or toilet themselves.
They often experience severe and frequent seizures that are not responsive to medical therapies.
Our Mission
CureGRIN Foundation is dedicated to improving the lives of people around the world with GRI Disorders (GRIA, GRID, GRIK, and GRIN) and their families through research, education, and support. We work closely with scientists and the medical community to drive patient-centered research that will lead to treatments and cures.
GRI Disorders may be rare, but hope should not be.
HOW CUREGRIN HELPS
Research &
Clinical Trials
Coming soon
Awareness &
Advocacy
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Start Here
For
Parents
Support,
Understanding, and Hope
Navigating a GRI Disorder diagnosis can be overwhelming. This section offers trusted resources, guidance, and a supportive community for parents and caregivers.
Learn about genetic markers, available treatments, and how to connect with others on the same journey.
For
Researchers/Clinicians
Advancing Knowledge
Through Collaboration
Access the latest research, clinical data, and collaboration opportunities focused on GRI Disorders and their genetic underpinnings.
This is designed to support the scientific community in pushing forward diagnostics, treatments, and patient outcomes.
Coming Soon
For
Industry
Innovate Together
for Greater Impact
Explore how your organization can partner with us to accelerate breakthroughs in GRI Disorder research. From data sharing to co-development opportunities, we’re building a collaborative ecosystem to turn insights into action for affected families worldwide.
Coming Soon
News
Stay informed with the latest research breakthroughs, upcoming events, and CureGRIN related news. See what’s happening in the fight against GRI Disorders.
A Family’s Guide to the Combined Brain Biorepository
Cure in Progress Report: August 2025
our impact
Lifetime dollar value of research
grants awarded since 2018.
Attendees for our GRICON25 event.
Researchers in CureGRIN’s
global research network.
Participants in GRI Census.
GRI Stories
Families at the Heart of Our Mission
Behind every diagnosis is a child with a story to tell. These powerful accounts shed light on the realities of living with GRI Disorders and the importance of advancing research and support.
FAQs
There is currently no cure for GRI disorders. In fact, 95% of all rare diseases have no FDA-approved treatment. This is why we are actively seeking treatments and cures for GRI disorders and need your help to achieve this mission! However, there are drugs that sometimes help to treat symptoms, as well as off-label medications and supplements that appear to be helpful for certain patients, depending on the affected gene and variant. These include the supplement L-Serine for GRIN patients with loss-of-function variants, Memantine for GRI patients with gain-of-function variants; and Perampanel for gain-of-function GRIA Disorders. Parents should work closely with a knowledgeable physician before trialing a new drug.
The predicted incidence (frequency of disorder) per 100,000 births is 5.45 for GRIN1, 3.23 for GRIN2A, 5.91 for GRIN2B, 4.61 for GRIN2D, 2.55 for GRIA1, 2.79 for GRIA2, 2.48 for GRIA3, 2.08 for GRIA4, and 1.87 for GRIK2 (López-Rivera, 2020; Lemke, 2020). In 2020, Dr. Johannes Lemke (University of Leipzig, Germany) calculated that GRIN Disorders due to variants in either GRIN1, GRIN2A, GRIN2B or GRIN2D occur in one out of every 5,208 births (19.2 per 100,000).
Accelerating Research: We fund and lead cutting-edge research to find therapies and cures. Your donations help us invest in crucial studies, build collaborative networks among scientists and clinicians, and advocate for our community to get the attention and resources it needs.
Empowering the Community: We provide essential education, resources, and a supportive community for families affected by GRI disorders. Your contribution helps us develop educational materials, host community events, and connect families worldwide.
Finding Treatments and Cures: Your support helps us find treatments and cures for GRI disorders by investing in groundbreaking research and collaborating with biotechnology and pharmaceutical companies. Together, we can find a clear path forward for those affected by GRI disorders.