Research

Funding GRIN Disorder research to find a cure

There is currently no cure for GRIN Disorders.

 

Fortunately, there is hope.   

Scientists working at hospitals, universities, and pharmaceutical / biotechnology companies around the world are studying NMDA receptors and the GRIN genes that code them. Some believe a cure (or multiple cures) will be discovered for GRIN Disorders in the next ten to twenty years. Preliminary research suggests that if a malfunctioning GRIN gene is “mended,” brain function could improve dramatically, even in adults who have lived with GRIN1, GRIN2A, GRIN2B, or other GRIN Disorders for decades. 

Scientists are moving on two tracks in their search for a cure

 

  1. Development of new drugs. The NMDA receptor responds well to drug therapies. So, scientists are seeking compounds that can speed up the NMDA receptor in Loss of Function patients or slow down the NMDA receptor in patients with Gain of Function. ​

  2. Gene editing. Through a recently discovered tool known as CRISPR, scientists can edit a DNA sequence to repair a deviated gene. This technology is already in widespread use in plants and animals, and scientists are at the beginning stages of testing it on humans. While the brain is a challenging target for CRISPR, researchers are confident they will one day be able to use CRISPR to cure GRIN Disorders. 

Many believe a cure (or multiple cures) will be discovered for GRIN Disorders in the next ten years

CureGRIN's approach to finding a cure

We are following a three-pronged approach in our effort to find a cure for GRIN Disorders.

  1. Funding foundational research that will lower the barriers to studying GRIN Disorders

  2. Investing directly into research projects to find therapies and cures

  3. Building a Research Network for GRIN Disorders

Funding foundational research that will lower the barriers to studying GRIN Disorders

 

In order to attract more researchers at universities, hospitals and biotech firms, CureGRIN prioritizes the following types of investments:

  • Patient Registry

  • Natural History Study

  • Animal Models

  • Identification of Biomarkers

Investing directly in research projects to find therapies and cures

We invest in researchers and research projects that have the best chances of leading to cures and therapies for patients with GRIN Disorders.

Building a Research Network for GRIN Disorders

We believe in breaking down barriers between researchers at universities, hospitals and biotech companies in order to promote the sharing of everything from ideas and research to animal models and technologies.

  • We communicate regularly with researchers around the world, and our Scientific Advisory Board includes the world leading experts in GRIN Disorders and NMDA Receptors. 

  • We have travelled to meet with leading researchers at hospitals, universities and biotech companies in order to raise awareness about GRIN Disorders.

  • As a result of our outreach, several biotech companies are undertaking research to find cures and therapies for GRIN Disorders.

  • We are sponsoring and helping to coordinate the world's first global academic conference on GRIN Disorders at Emory University in Atlanta in September of 2019.

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© 2019 by CureGRIN Foundation